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A collaboration between 34 researchers at 18 institutions has looked into the efficacy and safety of psilocybin in patients with major depressive disorder.

Researchers found a rapid onset of antidepressant effects, sustained reduction in depressive symptoms, and improvement in psychosocial functioning associated with a single 25mg dose of psilocybin administered with psychological support in patients with major depressive disorder (MDD).

The study suggests that psilocybin treatment positively impacted various aspects of mental health and well-being beyond just reducing depressive symptoms, as it improved overall functioning, anxiety symptoms, and quality of life in the study participants.

Several studies in recent years have suggested that psilocybin causes a rapid antidepressant response that far outlasts the presence of the drug in the body and an absence of withdrawal symptoms.

Source: Medical Xpress